Neurochemistry and Neuroendocrinology of Schizophrenia: A Selective Review
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چکیده
منابع مشابه
Neurochemistry and neuroendocrinology of schizophrenia: a selective review.
Neurochemical investigation has played a major role in the search for the cause of schizophrenia. Initial research strategies involved the direct measurement of neurochemical substances in biological fluids. Subsequently, indirect measures of brain biochemistry including pituitary hormones and responses to pharmacologic probes were examined. Recent advances in in vivo functional neuroimaging, b...
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Neurochemistry of Schizophrenia: Glutamatergic Abnormalities
Multiple neurotransmitters have been implicated in schizophrenia. Dopamine is the neurotransmitter most often hypothesized to be associated with the pathophysiology of schizophrenia for two reasons. First, dopaminergic agonists can cause or exacerbate psychotic symptoms. Second, the correlation between antipsychotic efficacy and D2 dopamine-receptor blockade is excellent. For these reasons, a n...
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This chapter is a review of the evidence implicating a dysfunction of dopamine transmission inthe prefrontal cortex in schizophrenia, underlying negative symptoms and cognitive deficits. The evidencederives essentially from brain imaging studies, post-mortem studies and clinical pharmacological studies.The imaging studies have suggested alterations in the main mediator of dopamine t...
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Studies aiming to identify susceptibility genes for schizophrenia and other complex psychiatric disorders are faced with the confounds of subjective clinical criteria, commonly occurring phenocopies, significant between-subject variability of candidate traits, and the likelihood of allelic and locus heterogeneity that has been shown to define the genetics of other complex human brain and somati...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 1993
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/19.2.371